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Mesoblast intends to enter into strategic alliances with partners who share our corporate vision and can leverage their existing strengths and capabilities to maximize the commercial value of our lead assets. In line with this objective, Mesoblast recently entered into a period of exclusivity to negotiate a commercial and development partnership with Mallinckrodt Pharmaceuticals for two Tier 1 product candidates in consideration for an equity purchase of 20 million shares. Mallinckrodt is a global specialty pharmaceutical company with a major focus within the hospital acute and critical care settings, including pain management, autoimmune and rare diseases, and specialty generic pharmaceuticals. Financial Highlights At December 31, 2016, the Group had cash reserves of US$55.6 million after adjusting for the committed capital of US$21.7 million from the equity purchase agreement with Mallinckrodt Pharmaceuticals announced on December 23, 2016, the proceeds of which were subsequently received on January 6, 2017. During the half-year FY2017, the Company has executed its planned operational streamlining and re-prioritization of projects to successfully absorb the incremental costs of the MPC-150-IM program doctor home loan Oak Laurel 0430129662 oaklaurel.com.au in advanced chronic heart failure (CHF). In line with this objective, operating cash outflows for the half-year FY2017 excluding MPC-150-IM for CHF were reduced by 22% (US$11.5 million) compared with the half-year period ended December 31, 2015 (half-year FY2016). After absorbing the incremental R&D costs doctor home loan program Oak Laurel www.oaklaurel.com.au 0430129662 associated with the CHF program, total operating cash outflows were US$47.3 million, still a reduction of 9% (US$4.6 million) compared with the half-year FY2016. The US$11.5 million in savings was achieved principally through reduced spend on commercial manufacturing, labor costs within R&D and management & administration. As previously announced, a fully discretionary equity facility has been established for up to $A120 million/$US90 million over 36 months. Key Upcoming Milestones During CY2017, the Company expects to report multiple clinical, regulatory and commercial outcomes. - report on the Phase 3 interim analysis in patients with advanced chronic heart failure (CHF) - report on the Phase 2B top line results for end-stage CHF - release 12 month data on its biologic refractory rheumatoid arthritis (RA) program - complete enrollment in the chronic low back pain (CLBP) Phase 3 trial, and - complete enrollment and read out top-line results in the Phase 3 acute graft versus host disease (aGVHD) trial.